Publications
2010
- Qing, Min; Liu, Wei; Yuan, Zhiming; Gu, Feng; Shi, Pei Yong. Novartis Institute for Tropical Diseases, Singapore. A high-throughput assay using dengue-1 virus-like particles for drug discovery. Antiviral Research (2010), 86(2), 163-171. Publisher: Elsevier B.V., CODEN: ARSRDR ISSN: 0166-3542. Journal written in English. CAN 153:31906 AN 2010:459713 CAPLUS (Copyright © 2010 ACS on SciFinder (R))
- Dartois, Veronique; Barry, Clifton E. Novartis Institute for Tropical Diseases, Biopolis, Singapore. Clinical pharmacology and lesion penetrating properties of second-and third-line antituberculous agents used in the management of multidrug-resistant (MDR) and extensively-drug resistant (XDR) tuberculosis. Current Clinical Pharmacology (2010), 5(2), 96-114. Publisher: Bentham Science Publishers Ltd., CODEN: CCPUC5 ISSN: 1574-8847. Journal written in English. AN 2010:715227 CAPLUS (Copyright © 2010 ACS on SciFinder (R))
- Chung, Ka-Yan; Dong, Hong-Ping; Chao, Alexander Theodore; Shi, Pei-Yong; Lescar, Julien; Lim, Siew-Pheng. Novartis Institute for Tropical Diseases, Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus. Singapore. Virology (2010), 402(1), 52-60. Publisher: Elsevier B.V., CODEN: VIRLAX ISSN: 0042-6822. Journal written in English. AN 2010:614361 CAPLUS (Copyright © 2010 ACS on SciFinder (R))
- Niyomrattanakit, Pornwaratt; Chen, Yen-Liang; Dong, Hongping; Yin, Zheng; Qing, Min; Glickman, J. Frasier; Lin, Kai; Mueller, Dieter; Voshol, Hans; Lim, Joanne Y. H.; Nilar, Shahul; Keller, Thomas H.; Shi, Pei-Yong. Novartis Institute for Tropical Diseases, Singapore, Singapore. Inhibition of Dengue virus polymerase by blocking of the RNA tunnel. Journal of Virology (2010), 84(11), 5678-5686. Publisher: American Society for Microbiology, CODEN: JOVIAM ISSN: 0022-538X. Journal written in English. AN 2010:662770 CAPLUS (Copyright © 2010 ACS on SciFinder (R))
- Chen Yen-Liang; Yin Zheng; Duraiswamy Jeyaraj; Schul Wouter; Lim Chin Chin; Liu Boping; Xu Hao Ying; Qing Min; Yip Andy; Wang Gang; Chan Wai Ling; Tan Hui Pen; Lo Melissa; Liung Sarah; Kondreddi Ravinder Reddy; Rao Ranga; Gu Helen; He Handan; Keller Thomas H; Shi Pei-Yong Novartis Institute for Tropical Diseases, 10 Biopolis Road, No. 05-01 Chromos, 138670, Singapore. Inhibition of dengue virus RNA synthesis by an adenosine nucleoside. Antimicrobial agents and chemotherapy (2010), 54(7), 2932-9. Journal code: 0315061. E-ISSN:1098-6596. Journal; Article; (JOURNAL ARTICLE) written in English. PubMed ID 20457821 AN 2010509048 In-process for MEDLINE (Copyright © 2010 U.S. National Library of Medicine on SciFinder (R))
- Gengenbacher, Martin; Rao, Srinivasa P. S.; Pethe, Kevin; Dick, Thomas. Novartis Institute for Tropical Diseases Pte Ltd, Singapore, Singapore. Nutrient-starved, nonreplicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability. Microbiology (Reading, United Kingdom) (2010), 156(1), 81-87. Publisher: Society for General Microbiology, CODEN: MROBEO ISSN: 1350-0872. Journal written in English. CAN 152:473086 AN 2010:189126 CAPLUS (Copyright © 2010 ACS on SciFinder (R))
- Yeung, Bryan K.; Zou, Bin; Rottmann, Matthias; Lakshminarayana, Suresh B.; Ang, Shi Hua; Leong, Seh Yong; Tan, Jocelyn; Wong, Josephine; Goh, Anne; Keller-Maerki, Sonja; Fischli, Christoph; Schmitt, Esther; Krastel, Philipp; Francotte, Eric; Kuhen, Kelli; Henson, Kerstin; Wagner, Trixie; Plouffe, David; Winzeler, Elizabeth A.; Petersen, Frank; Brun, Reto; Dartois, Veronique; Keller, Thomas H.; Diagana, Thierry T. Novartis Institute for Tropical Diseases, Singapore, Singapore. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 (2010), MEDI-29. Publisher: American Chemical Society, Washington, D. C CODEN: 69MML8 Conference; Meeting Abstract; Computer Optical Disk written in English. AN 2010:344573 CAPLUS (Copyright © 2010 ACS on SciFinder (R))
- Noble, Christian G.; Chen, Yen-Liang; Dong, Hongping; Gu, Feng; Lim, Siew Pheng; Schul, Wouter; Wang, Qing-Yin; Shi, Pei-Yong. Novartis Institute for Tropical Diseases, 05-01 Chromos, Singapore. Strategies for development of dengue virus inhibitors. Antiviral Research (2010), 85(3), 450-462. Publisher: Elsevier B.V., CODEN: ARSRDR ISSN: 0166-3542. Journal; General Review written in English. CAN 152:372539 AN 2010:261354 CAPLUS (Copyright © 2010 ACS on SciFinder (R))
- Bodenreider, Christophe; Beer, David; Keller, Thomas H.; Sonntag, Sebastian; Wen, Daying; Yap, Li Jian; Yau, Yin Hoe; Shochat, Susana Geifman; Huang, Danzhi; Zhou, Ting; Caflisch, Amedeo; Su, Xun-Cheng; Ozawa, Kiyoshi; Otting, Gottfried; Vasudevan, Subhash G.; Lescar, Julien; Lim, Siew Pheng. Novartis Institute for Tropical Diseases, Chromos, Singapore. A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease. Analytical Biochemistry (2009), 395(2), 195-204. Publisher: Elsevier B.V., CODEN: ANBCA2 ISSN: 0003-2697. Journal written in English. CAN 152:51178 AN 2009:1255094 CAPLUS (Copyright © 2010 ACS on SciFinder (R))
- Nzila, A (Nzila, Alexis); Rottmann, M (Rottmann, Matthias); Chitnumsub, P (Chitnumsub, Penchit); Kiara, SM (Kiara, Stevens M.); Kamchonwongpaisan, S (Kamchonwongpaisan, Sumalee); Maneeruttanarungroj, C (Maneeruttanarungroj, Cherdsak); Taweechai, S (Taweechai, Supannee); Yeung, BKS (Yeung, Bryan K. S.); Goh, A (Goh, Anne); Lakshminarayana, SB (Lakshminarayana, Suresh B.); Zou, B (Zou, Bin); Wong, J (Wong, Josephine); Ma, NL (Ma, Ngai Ling); Weaver, M (Weaver, Margaret); Keller, TH (Keller, Thomas H.); Dartois, V (Dartois, Veronique); Wittlin, S (Wittlin, Sergio); Brun, R (Brun, Reto); Yuthavong, Y (Yuthavong, Yongyuth); Diagana, TT (Diagana, Thierry T.) Preclinical Evaluation of the Antifolate QN254, 5-Chloro-N ' 6 '-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54 (6): 2603-2610 JUN 2010
- Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT. Spiroindolones, a potent compound class for the treatment of malaria Science. 2010 Sep 3;329(5996):1175-80.
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